We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Evaluation of neutrophil-lymphocyte ratio in patients with early-stage mycosis fungoides.
- Authors
Eren, Rafet; Nizam, Nihan; Doğu, Mehmet; Mercan, Sevgi; Erdemir, Aslı; Suyanı, Elif; Doğu, Mehmet Hilmi; Erdemir, Aslı Vefa Turgut; Suyanı, Elif
- Abstract
Neutrophil-lymphocyte ratio (NLR), an indicator of inflammation, has been lately demonstrated as a prognostic factor and an indicator of disease activity in various diseases. However, the effects of NLR have not been investigated in mycosis fungoides (MF) patients yet. The aim of this study is to investigate the relationship between the NLR and treatment demand (systemic PUVA and/or chemotherapy), time to treatment, progression in stage, and time to progression in stage in MF patients. The data of 117 patients, who were followed with the diagnosis of MF at the Department of Dermatology in Istanbul Training and Research Hospital between April 2006 and January 2016, were analyzed retrospectively. The cutoff score for NLR was determined as 2 according to the median NLR level which was 1.96. At the time of diagnosis, the median age of patients was 54 years (range, 21-90) with 62 (53 %) female and 55 (47 %) male. Seventy-seven (65.8 %) patients required treatment during follow-up. Sixty-three (53.8 %) patients showed progression in disease stage. There was no significant difference in treatment demand, time to treatment, progression in stage, and time to progression in stage in patients with a NLR ≥ 2 and NLR < 2 (p = 0.331, 0.987, 0.065, and 0.119, respectively). It seems that there is no association between the NLR and treatment demand, time to treatment, progression in stage, and time to progression in stage in MF patients.
- Subjects
LYMPHOCYTES; NEUTROPHIL immunology; IMMUNOLOGY of inflammation; MYCOSIS fungoides; PATIENTS; DIAGNOSIS; THERAPEUTICS; ANTINEOPLASTIC agents; DOXORUBICIN; NEUTROPHILS; PHOTOCHEMOTHERAPY; PREDNISONE; PROGNOSIS; TUMOR classification; VINCRISTINE; RETROSPECTIVE studies; CYCLOPHOSPHAMIDE; DISEASE progression; KAPLAN-Meier estimator; LEUKOCYTE count
- Publication
Annals of Hematology, 2016, Vol 95, Issue 11, p1853
- ISSN
0939-5555
- Publication type
journal article
- DOI
10.1007/s00277-016-2779-7