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- Title
Racial Disparities in Liver Transplantation for Hepatocellular Carcinoma in the United States: An Update.
- Authors
Kilani, Yassine; Kamal, Syeda Ashna Fatima; Vikash, Fnu; Vikash, Sindhu; Aldiabat, Mohammad; Alsakarneh, Saqr; Aljabiri, Yazan; Sohail, Haris; Kumar, Vikash; Numan, Laith; Al Khalloufi, Kawtar
- Abstract
Background: Previous studies have demonstrated a disparity in liver transplantation (LT) for hepatocellular carcinoma (HCC) among races in the United States (U.S.). Aims: We aimed to update the literature on the odds, trends, and complications of LT in the treatment of hepatocellular carcinoma (HCC), among individuals of different racial backgrounds. Methods: This is a nationwide study of adult individuals admitted for LT with a primary diagnosis of HCC. Using weighted data from the National Inpatient Sample (NIS) database, we compared the odds of LT among different races from 2016 to 2020, using a multivariate regression analysis. We further assessed the trends and outcomes of LT among races. Results: A total of 112,110 adult were hospitalized with a primary diagnosis of HCC. 3020 underwent LT. When compared to Whites, the likelihood of undergoing LT for HCC was significantly reduced in Blacks (OR = 0.60, 95% CI = 0.46–0.78). Further, Blacks had increased mortality rates (7% in Blacks vs. 1% in Whites, p < 0.001), sepsis (11% in Blacks vs. 3% in Whites, p = 0.015), and acute kidney injury (AKI) (54% in Blacks vs. 31% in Whites, p < 0.001) following LT. Conclusions: Individuals identifying as Blacks were less likely to undergo LT for HCC, and more likely to develop complications. Further initiatives are warranted to mitigate the existing disparities among racial groups.
- Subjects
UNITED States; RACIAL inequality; HEPATOCELLULAR carcinoma; LIVER transplantation; BLACK people; ACUTE kidney failure
- Publication
Digestive Diseases & Sciences, 2023, Vol 68, Issue 10, p4050
- ISSN
0163-2116
- Publication type
Article
- DOI
10.1007/s10620-023-08084-z