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- Title
Evaluation of the International Consensus Guidelines for the Surgical Resection of Intraductal Papillary Mucinous Neoplasms.
- Authors
Tsukagoshi, Mariko; Araki, Kenichiro; Saito, Fumiyoshi; Kubo, Norio; Watanabe, Akira; Igarashi, Takamichi; Ishii, Norihiro; Yamanaka, Takahiro; Shirabe, Ken; Kuwano, Hiroyuki
- Abstract
<bold>Background: </bold>International consensus guidelines for intraductal papillary mucinous neoplasms (IPMNs) were revised in 2012.<bold>Aims: </bold>We aimed to evaluate the clinical utility of each predictor in the 2006 and 2012 guidelines and validate the diagnostic value and surgical indications.<bold>Methods: </bold>Forty-two patients with surgically resected IPMNs were included. Each predictor was applied to evaluate its diagnostic value.<bold>Results: </bold>The 2012 guidelines had greater accuracy for invasive carcinoma than the 2006 guidelines (64.3 vs. 31.0%). Moreover, the accuracy for high-grade dysplasia was also increased (48.6 vs. 77.1%). When the main pancreatic duct (MPD) size ≥8 mm was substituted for MPD size ≥10 mm in the 2012 guidelines, the accuracy for high-grade dysplasia was 80.0%.<bold>Conclusions: </bold>The 2012 guidelines exhibited increased diagnostic accuracy for invasive IPMN. It is important to consider surgical resection prior to invasive carcinoma, and high-risk stigmata might be a useful diagnostic criterion. Furthermore, MPD size ≥8 mm may be predictive of high-grade dysplasia.
- Subjects
MUCINOUS adenocarcinoma; PAPILLARY muscles; SURGICAL excision; TUMOR diagnosis; CANCER invasiveness; MEDICAL protocols
- Publication
Digestive Diseases & Sciences, 2018, Vol 63, Issue 4, p860
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-017-4667-y