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- Title
Controlled Attenuation Parameter (CAP) with the XL Probe of the Fibroscan<sup>®</sup>: A Comparative Study with the M Probe and Liver Biopsy.
- Authors
Lédinghen, Victor; Hiriart, Jean-Baptiste; Vergniol, Julien; Merrouche, Wassil; Bedossa, Pierre; Paradis, Valérie; de Lédinghen, Victor; Paradis, Valérie
- Abstract
<bold>Introduction: </bold>Controlled attenuation parameter (CAP) is a new method for the diagnosis of steatosis. Until now, CAP was available only with the M probe of the Fibroscan. The aim of this study was to evaluate the diagnostic performance of CAP with the XL probe versus CAP with the M probe, using liver biopsy (LB) as gold standard.<bold>Patients and Methods: </bold>A total of 236 patients with chronic liver disease undergoing LB had CAP measurement with M and XL probes the same day. All LB were analyzed independently by two experienced pathologists.<bold>Results: </bold>Median CAP was 240.5 and 239.5 dB/m with the M and XL probes, respectively. For the detection of steatosis grade with the M and XL probes, AUROCs were 0.82/0.83 for S ≥ 1, 0.89/0.88 for S ≥ 2, and 0.92/0.93 for S3, respectively. Cutoffs were (M and XL probes) 246/242 for S ≥ 1, 269/267 for S ≥ 2, and 285/286 dB/m for S3, respectively. The factor significantly associated with CAP with the M and XL probes was steatosis grade. In multivariate analysis, a low CAP value with XL probe was negatively associated with waist circumference, triglycerides, albumin, and the alcohol consumption, and positively with alkaline phosphatases. In multivariate analysis, a high CAP value with the XL probe was positively associated with waist circumference and triglycerides.<bold>Conclusion: </bold>CAP with the XL probe is a new tool for the diagnosis of steatosis. This parameter could be useful for the diagnosis and the follow-up of obese patients.
- Subjects
LIVER biopsy; FATTY liver; FATTY degeneration; LIVER abnormalities; ELASTOGRAPHY; OBESITY complications; METABOLIC syndrome; DIAGNOSIS
- Publication
Digestive Diseases & Sciences, 2017, Vol 62, Issue 9, p2569
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-017-4638-3