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- Title
Extra-Gastrointestinal Manifestations of Inflammatory Bowel Disease May Be Less Common Than Previously Reported.
- Authors
Card, Timothy; Langan, Sinéad; Chu, Thomas; Card, Timothy R; Langan, Sinéad M; Chu, Thomas P C
- Abstract
<bold>Background and Aims: </bold>Extra-intestinal manifestations are well recognized in inflammatory bowel disease (IBD). To what extent the commonly recognized extra-intestinal manifestations seen in IBD patients are attributable to IBD is, however, not clear due to the limited number of controlled studies published.<bold>Methods: </bold>We have conducted a study of these manifestations using electronic primary care records. We have identified extra-intestinal manifestations in IBD and non-IBD patients and derived odds ratios (ORs) using conditional logistic regression.<bold>Results: </bold>A total of 56,097 IBD patients (32.5 % Crohn's disease, 48.3 % ulcerative colitis (UC) and 19.2 % not classified) were matched to 280,382 non-IBD controls. We found records of pyoderma gangrenosum (OR = 29.24), erythema nodosum (OR = 5.95), primary sclerosing cholangitis (OR = 188.25), uveitis (OR = 2.81), ankylosing spondylitis (OR = 7.07), sacroiliitis (OR = 2.79) and non-rheumatoid inflammatory arthritides (OR = 2.66) to be associated with IBD. One or more of these was recorded in 8.1 % of IBD patients and 2.3 % of controls. Non-specific arthritides were present in many more patients, affecting 30 % of IBD patients and 23.8 % of controls overall. We also found weaker associations with a number of conditions not generally considered to be extra-intestinal manifestations including psoriasis, ischemic heart disease, multiple sclerosis and hay fever.<bold>Conclusion: </bold>Although "classical" extra-intestinal manifestations are strongly associated with IBD, most IBD patients remain unaffected. Arthropathies, perceived to be the commonest extra-intestinal manifestation, are not strongly associated with IBD, and the proportion of arthropathies attributable to IBD is likely to be small.
- Subjects
INFLAMMATORY bowel diseases; LOGISTIC regression analysis; PSORIASIS; CORONARY disease; DIAGNOSIS; ULCERATIVE colitis; ERYTHEMA nodosum; PATIENTS; ANKYLOSING spondylitis; ARTHRITIS; BILE duct diseases; SEASONAL variations of diseases; ALLERGIC rhinitis; LONGITUDINAL method; MULTIPLE sclerosis; MULTIVARIATE analysis; UVEITIS; RETROSPECTIVE studies; CASE-control method; PYODERMA gangrenosum; ODDS ratio
- Publication
Digestive Diseases & Sciences, 2016, Vol 61, Issue 9, p2619
- ISSN
0163-2116
- Publication type
journal article
- DOI
10.1007/s10620-016-4195-1