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- Title
Low expression of pRB predicts disease relapse in early glottic cancer treated with transoral laser microsurgery.
- Authors
Lee, Li‐Ang; Fang, Tuan‐Jen; Li, Hsueh‐Yu; Huang, Chung‐Guei; Chen, Tse‐Ching; Liao, Chun‐Ta; Kang, Chung‐Jan; Chang, Kai‐Ping; Yen, Tzu‐Chen; Lee, Li-Ang; Fang, Tuan-Jen; Li, Hsueh-Yu; Huang, Chung-Guei; Chen, Tse-Ching; Liao, Chun-Ta; Kang, Chung-Jan; Chang, Kai-Ping; Yen, Tzu-Chen
- Abstract
<bold>Objectives/hypothesis: </bold>To elucidate the associations among the immunohistochemical expression of tumor markers, clinicopathological variables, and disease-free survival (DFS) in patients with early-stage glottic squamous cell carcinoma (SCC) who underwent transoral laser microsurgery (TLM) as the primary treatment.<bold>Study Design: </bold>Retrospective chart review.<bold>Methods: </bold>The records of consecutive patients with Tis-T2N0 glottic SCC who underwent TLM between August 1, 2012 and October 31, 2015 were reviewed. Expression of Bcl-2, pRB, p16INK4A , p53, c-Myc, E-cadherin, and EGFR was examined using tissue microarrays containing tumor specimens through immunohistochemistry. Three-year DFS rates were calculated.<bold>Results: </bold>A total of 65 consecutive patients were identified, of which 28 were excluded due to insufficient tissue (n = 22) and low biomarker quality (n = 6). Therefore, 37 patients with complete records were included. The included patients were significantly older and had a more advanced type of cordectomy than did the excluded patients (P = .015 and .009, respectively). According to the findings of univariate analysis, age, betel quid chewing, type of cordectomy, BCL-2 expression, and pRB expression significantly predicted 3-year DFS. According to the findings of multivariate analysis, age (adjusted hazard ratio: 0.94, 95% CI: 0.88-1.00), betel quid chewing (adjusted hazard ratio: 5.07, 95% CI: 1.32-19.44), and pRB expression (adjusted hazard ratio: 0.02, 95% CI: 0.00-0.28) were independent predictors of 3-year DFS.<bold>Conclusions: </bold>Low pRB expression is a potential biomarker for predicting disease relapse after primary TLM for early-stage glottic SCC and may help to identify high-risk patients who can subsequently undergo intensive management.<bold>Level Of Evidence: </bold>4 Laryngoscope, 129:E220-E226, 2019.
- Subjects
DISEASE relapse; CANCER relapse; MICROSURGERY; SQUAMOUS cell carcinoma; TUMOR markers; PROGRESSION-free survival
- Publication
Laryngoscope, 2019, Vol 129, Issue 6, pE220
- ISSN
0023-852X
- Publication type
journal article
- DOI
10.1002/lary.27612