We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Interactions between microsatellite instability and human gut colonization by Escherichia coli in colorectal cancer.
- Authors
Gagnière, Johan; Bonnin, Virginie; Jarrousse, Anne-Sophie; Cardamone, Emilie; Agus, Allison; Uhrhammer, Nancy; Sauvanet, Pierre; Déchelotte, Pierre; Barnich, Nicolas; Bonnet, Richard; Pezet, Denis; Bonnet, Mathilde
- Abstract
Recent studies suggest that colonization of colonic mucosa by pathogenic Escherichia coli could be involved in the development of colorectal cancer (CRC), especially through the production of genotoxins such as colibactin and/or by interfering with the DNA mismatch repair (MMR) pathway that leads to microsatellite instability (MSI). The present study, performed on 88 CRC patients, revealed a significant increase in E. coli colonization in the MSI CRC phenotype. In the same way, E. coli persistence and internalization were increased in vitro in MMR-deficient cells. Moreover, we demonstrated that colibactin-producing E. coli induce inhibition of the mutL homologue 1 (MLH1) MMR proteins, which could lead to genomic instability. However, colibactin-producing E. coli were more frequently identified in microsatellite stable (MSS) CRC. The present study suggests differences in the involvement of colibactin-producing E. coli in colorectal carcinogenesis according to the CRC phenotype. Further host--pathogen interactions studies should take into account CRC phenotypes.
- Subjects
ESCHERICHIA coli; COLON cancer; DNA mismatch repair; CARCINOGENESIS; CARCINOGENICITY
- Publication
Clinical Science, 2017, Vol 131, Issue 6, p471
- ISSN
0143-5221
- Publication type
Article
- DOI
10.1042/CS20160876