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- Title
A multifunctional enzyme is involved in bacterial ether lipid biosynthesis.
- Authors
Lorenzen, Wolfram; Ahrendt, Tilman; Bozhüyük, Kenan A J; Bode, Helge B
- Abstract
Fatty acid-derived ether lipids are present not only in most vertebrates but also in some bacteria. Here we describe what is to our knowledge the first gene cluster involved in the biosynthesis of such lipids in myxobacteria that encodes the multifunctional enzyme ElbD, which shows similarity to polyketide synthases. Initial characterization of elbD mutants in Myxococcus xanthus and Stigmatella aurantiaca showed the importance of these ether lipids for fruiting body formation and sporulation.
- Subjects
ENZYMES; ETHER lipids; BACTERIAL lipids; BIOSYNTHESIS; MYXOBACTERALES; POLYKETIDE synthases; MYXOCOCCUS xanthus; BACTERIAL sporulation
- Publication
Nature Chemical Biology, 2014, Vol 10, Issue 6, p425
- ISSN
1552-4450
- Publication type
Article
- DOI
10.1038/nchembio.1526