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- Title
Therapeutic Drug Monitoring Simulator for Antibiotic Dosage for Methicillin-Resistant Staphylococcus aureus Sepsis in a Patient with Primary Immunodeficiency on Peritoneal Dialysis.
- Authors
Hidehiko Narazaki; Yusuke Terada; Kiyohiko Kaizu; Toyo Jitsukawa; Yasuhiko Ito; Takeshi Asano
- Abstract
Bacterial infections often cause fatal systemic infections in patients with primary immunodeficiency. To prevent unfortunate results, the selection, dose, and dosage of antibiotics are extremely important. Here, we report a case of Wiskott-Aldrich syndrome in a patient undergoing peritoneal dialysis because of chronic renal failure in whom methicillin-resistant Staphylococcus aureus sepsis developed. Because of the primary disease and complications, teicoplanin was the only chosen anti-S. aureus drug to prevent side effects. We used parameter estimation and dosage adjustment from a therapeutic drug monitoring simulation software program to overcome the challenges with teicoplanin treatment.
- Subjects
DRUG monitoring; ANTIBIOTICS; DRUG dosage; STAPHYLOCOCCUS aureus infections; SEPTICEMIA treatment; PERITONEAL dialysis; PATIENTS; THERAPEUTICS
- Publication
Journal of Nippon Medical School, 2017, Vol 84, Issue 4, p177
- ISSN
1345-4676
- Publication type
Case Study
- DOI
10.1272/jnms.84.177