We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
ATF4 regulates lipid metabolism and thermogenesis.
- Authors
Chunxia Wang; Zhiying Huang; Ying Du; Ying Cheng; Shanghai Chen; Feifan Guo
- Abstract
Activating transcription factor 4 (ATF4) has been shown to play key roles in many physiological processes. There are no reports, however, demonstrating a direct link between ATF4 and lipid metabolism. We noticed that Atf4-deficient mice are lean, suggesting a possible role for ATF4 in regulating lipid metabolism. The goal of our current study is to investigate the involvement of ATF4 in lipid metabolism and elucidate the underlying mechanisms. Studies using Atf4-deficient mice revealed increased energy expenditure, as measured by oxygen consumption. These mice also showed increases in lipolysis, expression of uncoupling protein 2 (UCP2) and β-oxidation genes and decreases in expression of lipogenic genes in white adipose tissue (WAT), suggesting increased utilization and decreased synthesis of fatty acids, respectively. Expression of UCP1, 2 and 3 was also increased in brown adipose tissue (BAT), suggesting increased thermogenesis. The effect of ATF4 deletion on expression of UCPs in BAT suggests that increased thermogenesis may underlie increased energy expenditure. Thus, our study identifies a possible new function for ATF4 in regulating lipid metabolism and thermogenesis.
- Subjects
LIPID metabolism; BODY temperature regulation; LABORATORY mice; LIPOLYSIS; GENES
- Publication
Cell Research, 2010, Vol 20, Issue 2, p174
- ISSN
1001-0602
- Publication type
Article
- DOI
10.1038/cr.2010.4