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- Title
Raf kinase inhibitory protein: a signal transduction modulator and metastasis suppressor.
- Authors
Granovsky, Alexey E.; Rosner, Marsha Rich
- Abstract
Cells have a multitude of controls to maintain their integrity and prevent random switching from one biological state to another. Raf Kinase Inhibitory Protein (RKIP), a member of the phosphatidylethanolamine binding protein (PEBP) family, is representative of a new class of modulators of signaling cascades that function to maintain the “yin yang” or balance of biological systems. RKIP inhibits MAP kinase (Raf-MEK-ERK), G protein-coupled receptor (GPCR) kinase and NFκB signaling cascades. Because RKIP targets different kinases dependent upon its state of phosphorylation, RKIP also acts to integrate crosstalk initiated by multiple environmental stimuli. Loss or depletion of RKIP results in disruption of the normal cellular stasis and can lead to chromosomal abnormalities and disease states such as cancer. Since RKIP and the PEBP family have been reviewed previously, the goal of this analysis is to provide an update and highlight some of the unique features of RKIP that make it a critical player in the regulation of cellular signaling processes.Cell Research (2008) 18:452-457. doi: 10.1038/cr.2008.43; published online 1 April 2008
- Subjects
CYTOLOGY; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDIC acids; PHYSIOLOGY; CELLS
- Publication
Cell Research, 2008, Vol 18, Issue 4, p452
- ISSN
1001-0602
- Publication type
Article
- DOI
10.1038/cr.2008.43