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- Title
Ochratoxin A induces locomotor impairment and oxidative imbalance in adult zebrafish.
- Authors
Valadas, Jéssica; Sachett, Adrieli; Marcon, Matheus; Bastos, Leonardo M.; Piato, Angelo
- Abstract
Ochratoxin A (OTA) is a mycotoxin produced by species of filamentous fungi widely found as a contaminant in food and with high toxic potential. Studies have shown that this toxin causes kidney and liver damage; however, data on the central nervous system effects of exposure to OTA are still scarce. Thus, this study aimed to investigate the effects of exposure to OTA on behavioral and neurochemical parameters in adult zebrafish. The animals were treated with different doses of OTA (1.38, 2.77, and 5.53 mg/kg) with intraperitoneal injections and submitted to behavioral evaluations in the open tank and social interaction tests. Subsequently, they were euthanized, and the brains were used to assess markers associated with oxidative status. In the open tank test, OTA altered distance traveled, absolute turn angle, mean speed, and freezing time. However, no significant effects were observed in the social interaction test. Moreover, OTA also increased glutathione peroxidase (GPx), glutathione-S-transferase (GST), and glutathione reductase (GR) levels and decreased non-protein thiols (NPSH) levels in the zebrafish brain. This study showed that OTA can affect behavior and neurochemical levels in zebrafish.
- Subjects
BRACHYDANIO; ZEBRA danio; GLUTATHIONE reductase; GLUTATHIONE peroxidase; CENTRAL nervous system; INTRAPERITONEAL injections; POISONS
- Publication
Environmental Science & Pollution Research, 2023, Vol 30, Issue 8, p21144
- ISSN
0944-1344
- Publication type
Article
- DOI
10.1007/s11356-022-23692-4