We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Cortical sites critical to language function act as connectors between language subnetworks.
- Authors
Hsieh, Jason K.; Prakash, Prashanth R.; Flint, Robert D.; Fitzgerald, Zachary; Mugler, Emily; Wang, Yujing; Crone, Nathan E.; Templer, Jessica W.; Rosenow, Joshua M.; Tate, Matthew C.; Betzel, Richard; Slutzky, Marc W.
- Abstract
Historically, eloquent functions have been viewed as localized to focal areas of human cerebral cortex, while more recent studies suggest they are encoded by distributed networks. We examined the network properties of cortical sites defined by stimulation to be critical for speech and language, using electrocorticography from sixteen participants during word-reading. We discovered distinct network signatures for sites where stimulation caused speech arrest and language errors. Both demonstrated lower local and global connectivity, whereas sites causing language errors exhibited higher inter-community connectivity, identifying them as connectors between modules in the language network. We used machine learning to classify these site types with reasonably high accuracy, even across participants, suggesting that a site's pattern of connections within the task-activated language network helps determine its importance to function. These findings help to bridge the gap in our understanding of how focal cortical stimulation interacts with complex brain networks to elicit language deficits. It is unknown how cortical stimulation identifies brain regions critical to speech and language when they depend upon broader brain networks. Here the authors show that these critical areas function as connectors between modules in the language network.
- Publication
Nature Communications, 2024, Vol 15, Issue 1, p1
- ISSN
2041-1723
- Publication type
Article
- DOI
10.1038/s41467-024-51839-z