We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Identification of Cellular Isoschaftoside-Mediated Anti-Senescence Mechanism in RAC2 and LINC00294.
- Authors
Lee, Yun Haeng; So, Byeong Hyeon; Lee, Kyeong Seon; Kuk, Myeong Uk; Park, Ji Ho; Yoon, Jee Hee; Lee, Yoo Jin; Kim, Du Yeol; Kim, Min Seon; Kwon, Hyung Wook; Byun, Youngjoo; Lee, Ki Yong; Park, Joon Tae
- Abstract
As cellular senescence, reactive oxygen species (ROS) accumulate excessively, causing cellular damage. Flavonoids derived from natural products are known for their antioxidant effects and their ability to delay cellular senescence. Previous studies have attempted to mitigate cellular senescence using flavonoids from natural sources. However, the detailed mechanisms and regulatory targets of some flavonoids exhibiting antioxidant effects have not been fully elucidated. Therefore, we screened a library of flavonoids for antioxidant properties. Isoschaftoside, a glycosidic flavonoid, significantly reduced ROS levels in senescent cells. It was found that mitochondrial function was restored, and dependence on glycolysis was reduced in senescent cells treated with isoschaftoside. Additionally, we identified that isoschaftoside suppresses ROS by reducing the expression of RAC2 and LINC00294 in senescent cells. Taken together, this study establishes a novel mechanism for ROS inhibition and the regulation of cellular senescence by isoschaftoside. Our findings contribute important insights to antioxidant and anti-senescence research.
- Publication
Molecules, 2024, Vol 29, Issue 17, p4182
- ISSN
1420-3049
- Publication type
Article
- DOI
10.3390/molecules29174182