We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Effect of different doses of IV dexmedetomidine on spinal anesthesia with hyperbaric bupivacaine in Trans urethral resection of prostate surgery.
- Authors
Samal, Satyajit; Pattanayak, Sucheta; Tripathy, Bibekananda; Mohanty, Pratyaush Kumar; Dash, Laxmidhar
- Abstract
Aim:Aim of this study was to compare the characteristics of spinal block, hemodynamic changes, and postoperative analgesia, following administration of intravenous dexmedetomidine (0.25 mcg/kg and 0.5 mcg/kg) in patients undergoing TURP under spinal anaesthesia. Methods:90 patients of ASA grade I and II posted for elective transurethral resection of prostate surgeries were included in the study and randomly allocated into three groups. All three groups received 3ml of intrathecal 0.5% bupivacaine heavy, followed by infusion of study drug.Group D5 received intravenous dexmedetomidine 0.5mcg/kg over 10 min,Group D2 intravenous dexmedetomidine 0.25mcg/kg over 10 min and Group NS received infusion of same volume of normal saline as placebo.Duration of analgesia,time to 1st analgesia request,VAS score,hemodynamics and side effects were recorded and analyzed. Results:The prolongation in duration of analgesia in D5 group was statistically significant in comparison to other groups. Time to 1st analgesia request was delayed in group D5 compared to other groups which was statistically significant. Hemodynamic stability was well maintained in both dexmedetomidine group. Conclusion:Intravenous dexmedetomidine not only increased the duration of spinal analgesia but also maintained hemodynamic stability. IV Dexmedetomidine in a dose of 0.5 mcg/kg was more effective than 0.25 mcg/kg without increasing the risk of adverse effect.
- Subjects
PROSTATE surgery; SURGICAL excision; SPINAL anesthesia; DEXMEDETOMIDINE; INTRAVENOUS therapy; TRANSURETHRAL prostatectomy; SPINAL infusions
- Publication
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research), 2024, Vol 15, Issue 7, p1781
- ISSN
0975-3583
- Publication type
Article