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- Title
TDP-43 in nuclear condensates: where, how, and why.
- Authors
Lang, Ruaridh; Hodgson, Rachel E.; Shelkovnikova, Tatyana A.
- Abstract
TDP-43 is an abundant and ubiquitously expressed nuclear protein that becomes dysfunctional in a spectrum of neurodegenerative diseases. TDP-43's ability to phase separate and form/enter biomolecular condensates of varying size and composition is critical for its functionality. Despite the high density of phase-separated assemblies in the nucleus and the nuclear abundance of TDP-43, our understanding of the condensate- TDP-43 relationship in this cellular compartment is only emerging. Recent studies have also suggested that misregulation of nuclear TDP-43 condensation is an early event in the neurodegenerative disease amyotrophic lateral sclerosis. This review aims to draw attention to the nuclear facet of functional and aberrant TDP-43 condensation. We will summarise the current knowledge on how TDP-43 containing nuclear condensates form and function and how their homeostasis is affected in disease.
- Subjects
AMYOTROPHIC lateral sclerosis; NUCLEAR proteins; NEURODEGENERATION; CONDENSATION; HOMEOSTASIS
- Publication
Biochemical Society Transactions, 2024, Vol 52, Issue 4, p1809
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20231447