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- Title
DNA Methylation in Autism Spectrum Disorders: Biomarker or Pharmacological Target?
- Authors
Gholamalizadeh, Hanieh; Amiri-Shahri, Maedeh; Rasouli, Fatemeh; Ansari, Arina; Baradaran Rahimi, Vafa; Reza Askari, Vahid
- Abstract
Autism spectrum disorder (ASD) is a group of heterogeneous neurodevelopmental disabilities with persistent impairments in cognition, communication, and social behavior. Although environmental factors play a role in ASD etiopathogenesis, a growing body of evidence indicates that ASD is highly inherited. In the last two decades, the dramatic rise in the prevalence of ASD has interested researchers to explore the etiologic role of epigenetic marking and incredibly abnormal DNA methylation. This review aimed to explain the current understanding of the association between changes in DNA methylation signatures and ASD in patients or animal models. We reviewed studies reporting alterations in DNA methylation at specific genes as well as epigenome-wide association studies (EWASs). Finally, we hypothesized that specific changes in DNA methylation patterns could be considered a potential biomarker for ASD diagnosis and prognosis and even a target for pharmacological intervention.
- Subjects
AUTISM spectrum disorders; DNA methylation; DRUG therapy; RESEARCH personnel; ANIMAL models in research
- Publication
Brain Sciences (2076-3425), 2024, Vol 14, Issue 8, p737
- ISSN
2076-3425
- Publication type
Article
- DOI
10.3390/brainsci14080737