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- Title
Surgical Implications for Nonalcoholic Steatohepatitis-Related Hepatocellular Carcinoma.
- Authors
Anbarasu, Centura R.; Williams-Perez, Sophia; Camp, Ernest R.; Erstad, Derek J.
- Abstract
Simple Summary: Hepatocellular carcinoma (HCC) is an aggressive form of liver cancer that arises in a background of chronic hepatic injury. Metabolic syndrome-associated fatty liver disease (MAFLD) and its severe form, nonalcoholic steatohepatitis (NASH), are increasingly common mechanisms for new HCC cases. NASH-HCC patients are frequently obese and medically complex, creating challenges when considering interventional therapies. In this review, we discuss NASH-specific challenges and the associated implications for locoregional therapies, surgical resection, and liver transplantation. Hepatocellular carcinoma (HCC) is an aggressive form of liver cancer that arises in a background of chronic hepatic injury. Metabolic syndrome-associated fatty liver disease (MAFLD) and its severe form, nonalcoholic steatohepatitis (NASH), are increasingly common mechanisms for new HCC cases. NASH-HCC patients are frequently obese and medically complex, posing challenges for clinical management. In this review, we discuss NASH-specific challenges and the associated implications, including benefits of minimally invasive operative approaches in obese patients; the value of y90 as a locoregional therapy; and the roles of weight loss and immunotherapy in disease management. The relevant literature was identified through queries of PubMed, Google Scholar, and clinicaltrials.gov. Provider understanding of clinical nuances specific to NASH-HCC can improve treatment strategy and patient outcomes.
- Subjects
BARIATRIC surgery; RADIOISOTOPE therapy; NON-alcoholic fatty liver disease; WEIGHT loss; IMMUNOTHERAPY; MINIMALLY invasive procedures; METABOLIC syndrome; HEPATOCELLULAR carcinoma; DISEASE complications
- Publication
Cancers, 2024, Vol 16, Issue 16, p2773
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers16162773