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- Title
The Effects of Wubeizi Ointment on the Proliferation of Keloid-Derived Fibroblasts.
- Authors
Ding, Ji-cun; Tang, Zhi-ming; Zhai, Xiao-xiang; Chen, Xiang-hui; Li, Jing-guo; Zhang, Cui-xia
- Abstract
To evaluate the effectiveness of the Wubeizi (WBZ) ointment on keloid-derived fibroblasts. The primary cells of the keloid-derived fibroblasts were cultured and the effectiveness of the WBZ ointment at different concentrations was examined by MTT colorimetric methods on keloid-derived fibroblasts. The WBZ ointment showed inhibitory effects on proliferating the keloid-derived fibroblasts ( P < 0.01)in a time- and dose-dependent manner. The proportion of cells in S stage was significantly higher in each of the WBZ ointment group than in the control group ( P<0.01), and the proportion of G + M stage cells was significantly lower than that of control group, which was statistically significant ( P < 0.01).The inhibitory effects of the S and G + M stage increased with higher drug concentrations ( P < 0.05). Conclusion: The WBZ ointment can inhibit the proliferation of the keloid-derived fibroblasts in a time- and dose- dependent manner.
- Subjects
KELOIDS; FIBROBLASTS; OINTMENTS; MYOBLAST transfer therapy; COLORIMETRY
- Publication
Cell Biochemistry & Biophysics, 2015, Vol 71, Issue 1, p431
- ISSN
1085-9195
- Publication type
Article
- DOI
10.1007/s12013-014-0219-7