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- Title
Glabridin Inhibits Migration, Invasion, and Angiogenesis of Human Non–Small Cell Lung Cancer A549 Cells by Inhibiting the FAK/Rho Signaling Pathway.
- Authors
Tsai, Ying-Ming; Yang, Chih-Jen; Hsu, Ya-Ling; Wu, Ling-Yu; Tsai, Yu-Chieh; Hung, Jen-Yu; Lien, Chi-Tun; Huang, Ming-Shyan; Kuo, Po-Lin
- Abstract
This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non–small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of A549 cells. In addition, glabridin also decreased A549-mediated angiogenesis. Further investigation revealed that glabridin’s inhibition of cancer angiogenesis was also evident in a nude mice model. Blockade of A549 cells migration was associated with an increase of ανβ3 integrin proteosome degradation. Glabridin also decreased the active forms of FAK and Src, and enhanced levels of inactivated phosphorylated Src (Tyr 527), decreasing the interaction of FAK and Src. Inhibition of the FAK/Src complex by glabridin also blocked Akt activation, resulting in reduced activation of RhoA and myosin light chain phosphorylation. This study demonstrates that glabridin may be a novel anticancer agent for the treatment of lung cancer in 3 different ways: inhibition of migration, invasion, and angiogenesis.
- Subjects
GLYCYRRHIZA; ANALYSIS of variance; ANIMAL experimentation; BIOPHYSICS; CALCIUM-binding proteins; CELL motility; CYTOLOGICAL techniques; DIAGNOSIS; FLAVONOIDS; IMMUNOBLOTTING; LUNG cancer; RESEARCH methodology; MICE; NEOVASCULARIZATION inhibitors; PRECIPITIN reaction; RESEARCH funding; DATA analysis software; DESCRIPTIVE statistics; CHEMICAL inhibitors; THERAPEUTICS
- Publication
Integrative Cancer Therapies, 2011, Vol 10, Issue 4, p341
- ISSN
1534-7354
- Publication type
Article
- DOI
10.1177/1534735410384860