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- Title
Combined Photoredox/Enzymatic C−H Benzylic Hydroxylations.
- Authors
Betori, Rick C.; May, Catherine M.; Scheidt, Karl A.
- Abstract
Chemical transformations that install heteroatoms into C−H bonds are of significant interest because they streamline the construction of value‐added small molecules. Direct C−H oxyfunctionalization, or the one step conversion of a C−H bond to a C−O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single‐flask photoredox/enzymatic process for direct C−H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.
- Subjects
CHEMICAL amplification; SMALL molecules; NATURAL products; HYDROXYLATION; CATALYSIS
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 46, p16642
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201909426