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- Title
N‐Heterocyclic Carbene/Copper Cooperative Catalysis for the Asymmetric Synthesis of Spirooxindoles.
- Authors
Zhang, Zi‐Jing; Zhang, Ling; Geng, Rui‐Long; Song, Jin; Chen, Xiao‐Hua; Gong, Liu‐Zhu
- Abstract
Highly enantioselective [3+3] and [3+4] annulations of isatin‐derived enals with ethynylethylene carbonates and ethynyl benzoxazinanones are enabled by NHC/cooper cooperative catalysis, leading to a big library of spirooxindole derivatives in high structural diversity and enantioselectivity (up to 99 % ee). Both reactions represent a nicely synergistic integration of NHC and copper catalysis, in which both catalysts activate the substrates and the chiral NHC perfectly controls the stereochemistry.
- Subjects
CATALYSIS; STEREOCHEMISTRY; ASYMMETRIC synthesis; ANNULATION; CATALYSTS
- Publication
Angewandte Chemie, 2019, Vol 131, Issue 35, p12318
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201907188