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- Title
Copper‐Catalyzed Radical Cross‐Coupling of Redox‐Active Oxime Esters, Styrenes, and Boronic Acids.
- Authors
Yu, Xiao‐Ye; Zhao, Quan‐Qing; Chen, Jun; Chen, Jia‐Rong; Xiao, Wen‐Jing
- Abstract
A visible‐light‐driven, copper‐catalyzed three‐component radical cross‐coupling of oxime esters, styrenes, and boronic acids has been developed. Key steps of this protocol involve catalytic generation of an iminyl radical from a redox‐active oxime ester and subsequent C−C bond cleavage to generate a cyanoalkyl radical. Upon its addition to styrene, the newly formed benzylic radical undergoes coupling with a boronic‐acid‐derived ArCuII complex to achieve 1,1‐diarylmethane‐containing alkylnitriles.
- Subjects
COPPER; OXIDATION-reduction reaction; OXIMES; ESTERS; BORONIC acids
- Publication
Angewandte Chemie, 2018, Vol 130, Issue 47, p15731
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201809820