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- Title
Synthesis of 2-Indolyltetrahydroquinolines by Zinc(II)-Catalyzed Intramolecular Hydroarylation-Redox Cross-Dehydrogenative Coupling of N-Propargylanilines with Indoles.
- Authors
Li, Guangzhe; Nakamura, Hiroyuki
- Abstract
An intramolecular hydroarylation-redox cross-dehydrogenative coupling (CDC) of propargylic anilines with indoles proceeded in the presence of zinc(II) catalysts to give 2-indolyltetrahydroquinolines in good to high yields. Three C−H bonds (two sp2 and one sp3) are activated in one shot and these hydrogen atoms are trapped by a propargylic triple bond in the molecule.
- Subjects
AROMATIC compound synthesis; ZINC catalysts; ZINC compounds; OXIDATION-reduction reaction; INDOLE compounds; CARBON-hydrogen bonds
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 23, p6870
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201602416