We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Generation of Alkoxyl Radicals by Photoredox Catalysis Enables Selective C(sp<sup>3</sup>)−H Functionalization under Mild Reaction Conditions.
- Authors
Zhang, Jing; Li, Yang; Zhang, Fuyuan; Hu, Chenchen; Chen, Yiyun
- Abstract
Reported herein is the first visible-light-induced formation of alkoxyl radicals from N-alkoxyphthalimides, and the Hantzsch ester as the reductant is crucial for the reaction. The selective hydrogen atom abstraction by the alkoxyl radical enables C(sp3)−H allylation and alkenylation reactions under mild reaction conditions at room temperature. Broad substrate variations, including a structurally complexed steroid, undergo the C(sp3)−H functionalization reaction effectively with high regio- and chemoselectivity.
- Subjects
ALKOXYL radicals; CHEMOSELECTIVITY; CARBON-hydrogen bonds; PHOTOCHEMISTRY; REACTION mechanisms (Chemistry); ALLYLATION
- Publication
Angewandte Chemie, 2016, Vol 128, Issue 5, p1904
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201510014