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- Title
Difluorocarbene-Derived Trifluoromethylthiolation and [<sup>18</sup>F]Trifluoromethylthiolation of Aliphatic Electrophiles.
- Authors
Zheng, Jian; Wang, Lu; Lin, Jin‐Hong; Xiao, Ji‐Chang; Liang, Steven H.
- Abstract
The first trifluoromethylthiolation and [18F]trifluoromethylthiolation of alkyl electrophiles with in situ generated difluorocarbene in the presence of elemental sulfur and external (radioactive) fluoride ion is described. This transition-metal-free approach is high yielding, compatible with a variety of functional groups, and operated under mild reaction conditions. The conceptual advantage of this exogenous-fluoride-mediated transformation enables unprecedented syntheses of [18F]CF3S-labeled molecules from most commonly used [18F]fluoride ions. The rapid radiochemical reaction time (≤1 min) and high functional-group tolerance allow access to a variety of aliphatic [18F]CF3S compounds in high yields.
- Subjects
ELECTROPHILES; FUNCTIONAL groups; CARBENES; RADIOCHEMICAL research; CHEMICAL research
- Publication
Angewandte Chemie, 2015, Vol 127, Issue 45, p13434
- ISSN
0044-8249
- Publication type
Article
- DOI
10.1002/ange.201505446