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- Title
Current Advances in the Roles of Doped Bioactive Metal in Biodegradable Polymer Composite Scaffolds for Bone Repair: A Mini Review.
- Authors
Li, Fufen; Li, Shan; Liu, Yang; Zhang, Zetian; Li, Zhengjun
- Abstract
The election of bone tissue engineering scaffolds material is mainly based on the bionics of natural bones. Although the content of trace elements in bone is low, the lack of them affects the growth and metabolism of bones, thus increasing the risk of orthopedic diseases caused by the deterioration of bone quality. Therefore, inspired by trace elements in natural bone, biodegradable polymer composite scaffolds doped with bioactive metals such as Mg, Zn, Sr, Fe, Cu, Mn, Co, Li, Ag, Nb, and V have attracted more attention. Herein, the role of bioactive metals doping in biodegradable polymer matrix is mainly reviewed, including improving hydrophilicity, preventing aseptic inflammation caused by acidic degradation products, imparting antibacterial activity, improving mechanical properties, and promoting vascularization of polymer scaffolds. Then, the reasons and solutions for interfacial bonding and cytotoxicity caused by doping bioactive metals are focused on.
- Subjects
ORGANIC conductors; TRACE elements; BONE metabolism; TISSUE scaffolds; INTERFACIAL bonding; TISSUE engineering
- Publication
Advanced Engineering Materials, 2022, Vol 24, Issue 8, p1
- ISSN
1438-1656
- Publication type
Article
- DOI
10.1002/adem.202101510