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- Title
Succinate coenzyme A ligase β‐like protein from Trichinella spiralis is a potential therapeutic molecule for allergic asthma.
- Authors
Aimulajiang, Kalibixiati; Chu, Wen; Liao, Shuyi; Wen, Zhaohai; He, Rongdong; Lu, Mingmin; Xu, Lixin; Song, Xiaokai; Li, Xiangrui; Yan, Ruofeng
- Abstract
Background: For decades, studies have demonstrated the anti‐inflammatory potential of proteins secreted by helminths in allergies and asthma. Previous studies have demonstrated the immunomodulatory capabilities of Succinate Coenzyme A ligase beta‐like protein (SUCLA‐β) derived from Trichinella spiralis, a crucial excretory product of this parasite. Objective: To explore the therapeutic potential of SUCLA‐β in alleviating and controlling ovalbumin (OVA)‐induced allergic asthma, as well as its influence on host immune modulation. Methods: In this research, we utilized the rTs‐SUCLA‐β protein derived from T. spiralis to investigate its potential in mitigating airway inflammation in a murine model of asthma induced by OVA sensitization/stimulation, both pre‐ and post‐challenge. The treatment's efficacy was assessed by quantifying the extent of inflammation in the lungs. Results: Treatment with rTs‐SUCLA‐β demonstrated efficacy in ameliorating OVA‐induced airway inflammation, as evidenced by a reduction in eosinophil infiltration, levels of OVA‐specific Immunoglobulin E, interferon‐γ, interleukin (IL)‐9, and IL‐17A, along with an elevation in IL‐10. The equilibrium between Th17 and Treg cells plays a pivotal role in modulating the abundance of inflammatory cells within the organism, thereby ameliorating inflammation and alleviating symptoms associated with allergic asthma. Conclusions and Clinical Relevance: Our data revealed that T. spiralis‐derived Ts‐SUCLA‐β protein may inhibit the allergic airway inflammation by regulating host immune responses.
- Subjects
TRICHINELLA spiralis; OVALBUMINS; ASTHMA; IMMUNOGLOBULIN E; REGULATORY T cells; T helper cells
- Publication
Immunity, Inflammation & Disease, 2024, Vol 12, Issue 6, p1
- ISSN
2050-4527
- Publication type
Article
- DOI
10.1002/iid3.1321