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- Title
Interleukin-6 but not tumour necrosis factor-alpha predicts survival in patients with advanced cancer.
- Authors
Suh, Sang-Yeon; Choi, Youn; Yeom, Chang; Kwak, Sang; Yoon, Ho; Kim, Dae; Koh, Su-Jin; Park, Jeanno; Lee, Myung; Lee, Yong; Seo, Ah-Ram; Ahn, Hong-Yup; Yim, Eunji
- Abstract
Purpose: The purpose of this study was to evaluate the prognostic role of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in the survival of patients with advanced cancer. Methods: In this prospective cohort study between three hospice and palliative care centres in South Korea, we followed 98 advanced cancer patients until death or the end of the study. Approximately 60 % of the patients had poor functional status (Eastern Cooperative Oncology Group score ≥3). We investigated the symptoms of cancer cachexia anorexia syndrome, possible cytokine-related confounders such as infection and medication records. Influence from clinical variables was adjusted using the Cox proportional hazard model. Results: The median survival time was 27 days. On multivariate analysis, elevated IL-6 (hazard ratio, 2.139; p = 0.003) was found to be an independent significant prognostic factor. TNF-α was not a significant factor. Poor performance status and male gender were also independently related to shortened survival. Conclusions: IL-6 level can be a useful indicator of survival time of patients with advanced cancer at the very end of life. In contrast, the prognostic role of TNF-α requires further study.
- Subjects
INTERLEUKIN-6; TUMOR necrosis factors; CANCER patients; LONGITUDINAL method; PALLIATIVE treatment; HOSPICES; HOSPICE care; COHORT analysis
- Publication
Supportive Care in Cancer, 2013, Vol 21, Issue 11, p3071
- ISSN
0941-4355
- Publication type
Article
- DOI
10.1007/s00520-013-1878-4