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- Title
The protective effect of fish oil lipid emulsions on intestinal failure-associated liver disease in a rat model of short-bowel syndrome.
- Authors
Machigashira, Seiro; Kaji, Tatsuru; Onishi, Shun; Yamada, Waka; Yano, Keisuke; Yamada, Koji; Masuya, Ryuta; Kawano, Takafumi; Nakame, Kazuhiko; Mukai, Motoi; Ieiri, Satoshi
- Abstract
<bold>Purpose: </bold>Pediatric patients with intestinal failure need long-term parenteral nutrition (PN), but this nutritional support causes liver dysfunction, such as intestinal failure-associated liver disease (IFALD). Several studies have shown that the lipid emulsion produced by soybean oil (SO) is associated with the occurrence of IFALD. In this study, we evaluated the effect of SO and fish oil (FO) lipid emulsion on hepatic steatosis.<bold>Methods: </bold>Sprague-Dawley rats underwent jugular vein catheterization and were divided into three groups: sham operation with normal chow (Sham group), 80% small bowel resection (80% SBR) + TPN with SO lipid emulsion (SO group), and 80% SBR + TPN with FO lipid emulsion (FO group). All rats were euthanized and the serum biochemistry and hepatic histology analyzed.<bold>Results: </bold>No significant differences in the serum liver or biliary enzymes were noted between the SO and FO groups. The pathological findings and NAFLD score in the FO group did not show steatosis and were significantly lower than in the SO group. An analysis of the fatty acids profile in the both the SO and FO groups did not indicate essential fatty acid deficiency (EFAD).<bold>Conclusion: </bold>FO lipid emulsion may have a protective role against steatosis of IFALD without EFAD.
- Subjects
FISH oils; LIVER diseases; INTRAVENOUS fat emulsions; SHORT bowel syndrome; FATTY degeneration; ANIMAL models in research; ANIMAL experimentation; BIOLOGICAL models; LIVER failure; PARENTERAL feeding; RATS; DISEASE complications; PREVENTION
- Publication
Pediatric Surgery International, 2018, Vol 34, Issue 2, p203
- ISSN
0179-0358
- Publication type
journal article
- DOI
10.1007/s00383-017-4190-4