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- Title
Impact of SARS-CoV-2 viral load and duration of symptoms before hospital admission on the mortality of hospitalized COVID-19 patients.
- Authors
Rico-Caballero, Verónica; Fernández, Mariana; Hurtado, Juan C.; Marcos, M. Angeles; Cardozo, Celia; Albiach, Laia; Agüero, Daiana; Ambrosioni, Juan; Bodro, Marta; Chumbita, Mariana; De la Mora, Lorena; Garcia-Pouton, Nicole; Gonzalez-Cordón, Ana; Dueñas, Gerard; Hernandez-Meneses, Marta; Inciarte, Alexy; Laguno, Montse; Leal, Lorna; Macaya, Irene; Martínez, Miguel J.
- Abstract
Purpose: Assess the impact of viral load estimated by cycle threshold (Ct) of reverse transcription real time-polymerase chain reaction (rRT-PCR) and the days from symptoms onset on mortality in hospitalized patients with COVID19. Methods: Retrospective observational study of 782 patients with a positive rRT-PCR from a nasopharyngeal swab was performed within the first 24 h from admission. Demographic data, clinical manifestations and laboratory parameters were collected. Uni- and multivariate analyses were performed to identify factors associated with mortality at 60 days. Results: Ct was divided into three groups and the mortality rate decreased from 27.3 to 20.7% and 9.8% for Ct values of ≤ 20, 21–25 and > 25, respectively (P = 0.0001). The multivariate analysis identified as predictors of mortality, a Ct value < 20 (OR 3.13, CI 95% 1.38–7.10), between 21–25 (OR 2.47, CI 95% 1.32–4.64) with respect to a Ct value > 25. Days from symptoms onset is a variable associated with mortality as well (DSOA) ≤ 6 (OR 1.86, CI 95% 1.00–3.46), among other factors. Patients requiring hospital admission within 6 DSOA with a Ct value ≤ 25 had the highest mortality rate (28%). Conclusions: The inclusion of Ct values and DSOA in the characterization of study populations could be a useful tool to evaluate the efficacy of antivirals.
- Subjects
REVERSE transcriptase polymerase chain reaction; STATISTICS; COVID-19; SCIENTIFIC observation; CONFIDENCE intervals; VIRAL load; TIME; MULTIVARIATE analysis; PATIENTS; RETROSPECTIVE studies; HOSPITAL mortality; HOSPITAL admission &; discharge; COMPARATIVE studies; DESCRIPTIVE statistics; ODDS ratio
- Publication
Infection, 2022, Vol 50, Issue 5, p1321
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-022-01833-8