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- Title
Cardiac manifestations of COVID-19 in Shenzhen, China.
- Authors
Zeng, Jia-Hui; Wu, Wei-Bo; Qu, Jiu-Xin; Wang, Yao; Dong, Chang-Feng; Luo, Yong-Fang; Zhou, Dan; Feng, Wen-Xia; Feng, Cheng
- Abstract
Purpose: The coronavirus disease 2019 (COVID-19) outbreak has become a global public health concern; however, relatively few detailed reports of related cardiac injury are available. The aims of this study were to compare the clinical and echocardiographic characteristics of inpatients in the intensive-care unit (ICU) and non-ICU patients. Methods: We recruited 416 patients diagnosed with COVID-19 and divided them into two groups: ICU (n = 35) and non-ICU (n = 381). Medical histories, laboratory findings, and echocardiography data were compared. Results: The levels of myocardial injury markers in ICU vs non-ICU patients were as follows: troponin I (0.029 ng/mL [0.007–0.063] vs 0.006 ng/mL [0.006–0.006]) and myoglobin (65.45 μg/L [39.77–130.57] vs 37.00 μg/L [26.40–53.54]). Echocardiographic findings included ventricular wall thickening (12 [39%] vs 1 [4%]), pulmonary hypertension (9 [29%] vs 0 [0%]), and reduced left-ventricular ejection fraction (5 [16%] vs 0 [0%]). Overall, 10% of the ICU patients presented with right heart enlargement, thickened right-ventricular wall, decreased right heart function, and pericardial effusion. Cardiac complications were more common in ICU patients, including acute cardiac injury (21 [60%] vs 13 [3%]) (including 2 cases of fulminant myocarditis), atrial or ventricular tachyarrhythmia (3 [9%] vs 3 [1%]), and acute heart failure (5 [14%] vs 0 [0%]). Conclusion: Myocardial injury marker elevation, ventricular wall thickening, pulmonary artery hypertension, and cardiac complications including acute myocardial injury, arrhythmia, and acute heart failure are more common in ICU patients with COVID-19. Cardiac injury in COVID-19 patients may be related more to the systemic response after infection rather than direct damage by coronavirus.
- Subjects
CHINA; ATRIAL arrhythmias; ECHOCARDIOGRAPHY; HEART diseases; HEART failure; INTENSIVE care units; CARDIOMYOPATHIES; MYOGLOBIN; PULMONARY hypertension; TROPONIN; DESCRIPTIVE statistics; PERICARDIAL effusion; VENTRICULAR arrhythmia; VENTRICULAR ejection fraction; COVID-19; COVID-19 pandemic
- Publication
Infection, 2020, Vol 48, Issue 6, p861
- ISSN
0300-8126
- Publication type
Article
- DOI
10.1007/s15010-020-01473-w