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- Title
Longitudinal study of sodium MRI of articular cartilage in patients with knee osteoarthritis: initial experience with 16-month follow-up.
- Authors
Madelin, Guillaume; Xia, Ding; Brown, Ryan; Babb, James; Chang, Gregory; Krasnokutsky, Svetlana; Regatte, Ravinder R.
- Abstract
<bold>Objectives: </bold>To evaluate the potential of sodium MRI to detect changes over time of apparent sodium concentration (ASC) in articular cartilage in patients with knee osteoarthritis (OA).<bold>Methods: </bold>The cartilage of 12 patients with knee OA were scanned twice over a period of approximately 16 months with two sodium MRI sequences at 7 T: without fluid suppression (radial 3D) and with fluid suppression by adiabatic inversion recovery (IR). Changes between baseline and follow-up of mean and standard deviation of ASC (in mM), and their rate of change (in mM/day), were measured in the patellar, femorotibial medial and lateral cartilage regions for each subject. A matched-pair Wilcoxon signed rank test was used to assess significance of the changes.<bold>Results: </bold>Changes in mean and in standard deviation of ASC, and in their respective rate of change over time, were only statistically different when data was acquired with the fluid-suppressed sequence. A significant decrease (p = 0.001) of approximately 70 mM in mean ASC was measured between the two IR scans.<bold>Conclusion: </bold>Quantitative sodium MRI with fluid suppression by adiabatic IR at 7 T has the potential to detect a decrease of ASC over time in articular cartilage of patients with knee osteoarthritis.<bold>Key Points: </bold>• Sodium MRI can detect apparent sodium concentration (ASC) in cartilage • Longitudinal study: sodium MRI can detect changes in ASC over time • Potential for follow-up studies of cartilage degradation in knee osteoarthritis.
- Subjects
MAGNETIC resonance imaging; SODIUM; ARTICULAR cartilage; OSTEOARTHRITIS; WILCOXON signed-rank test; PATIENTS; KNEE diseases; LONGITUDINAL method; RESEARCH evaluation; RESEARCH funding; PILOT projects
- Publication
European Radiology, 2018, Vol 28, Issue 1, p133
- ISSN
0938-7994
- Publication type
journal article
- DOI
10.1007/s00330-017-4956-z