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- Title
Concentrative relationship between polymorphonuclear elastase and urinary trypsin inhibitor in amniotic fluid.
- Authors
Akutsu, H.; Iwama, H.
- Abstract
In the amniotic fluid, urinary trypsin inhibitor (UTI) seems to inhibit polymorphonuclear elastase (PMNE) activity. The PMNE and UTI concentrations in normal amniotic fluid at 16-20 and 38-40 gestational weeks were measured. The PMNE concentration increased significantly at 38-40 weeks, whereas UTI concentration decreased significantly. According to concentrative relationships between both substances, PMNE may be activated more at the full term pregnancy. Since PMNE-induced tissue injury potentially causes degradation of amniotic collagen, the present result suggests that the quotient of PMNE and UTI concentrations is a reliable index to estimate the occurrence of rupture of the membranes.
- Subjects
URINARY trypsin inhibitor; AMNIOTIC fluid embolism; PHYSIOLOGICAL therapeutics; TRYPSIN; ENZYME inhibitors; ELASTASES; GYNECOLOGY; GLYCOPROTEIN analysis; ABORTION; AMNIOCENTESIS; AMNIOTIC liquid; CESAREAN section; CREATININE; CORD blood; GESTATIONAL age; GLYCOPROTEINS; IMMUNOENZYME technique; NONPARAMETRIC statistics; PROTEOLYTIC enzymes; RADIOIMMUNOASSAY; PROTEASE inhibitors
- Publication
Archives of Gynecology & Obstetrics, 2000, Vol 263, Issue 4, p156
- ISSN
0932-0067
- Publication type
journal article
- DOI
10.1007/s004040050272