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- Title
The effect of lyophilized platelet rich-plasma on skin aging: a non-randomized, controlled, pilot trial.
- Authors
da Silva, Letícia Queiroz; Cancela, Rebeca Brito Bonani; de Lima Montalvão, Silmara Aparecida; Huber, Stephany Cares; Vieira-Damiani, Gislaine; Triglia, Renata Marchi; Annichino-Bizzacchi, Joyce Maria
- Abstract
Platelet-rich plasma (PRP) showed positive results in the improvement of skin aging. Lyophilized PRP can be interesting in clinical practice due to the facility to obtain many samples in a single blood collection and can be used in multiple injections. To evaluate the effect of lyophilized PRP in the treatment of skin aging, through a Phase II pilot study. Nineteen women (54 years ± 7 years) with Glogau photoaging II and III types were select for this non-randomized, split-face controlled study. They received monthly intradermal injections of lyophilized PRP and saline solution (as control) into the facial skin, during a period of 2 months. The evaluation was performed by imaging method, histological techniques, and multiphoton microscopy. Although lyophilized PRP presented 10 times the platelet baseline value (P <.0001) and growth factors in adequate levels, only saline solution showed an increase of dermis thickness (p =.0009). Collagen pre and post-application remained the same for both types of treatments. The use of lyophilized PRP by mesotherapy showed no improvement on skin aging. Trial registration approval: RBR-3n9wxw, UTN U1111-1226-6093-retrospectively registered.
- Subjects
SKIN aging; SALINE solutions; PLATELET-rich plasma; INTRADERMAL injections; HISTOLOGICAL techniques; BLOOD platelet transfusion; BLOOD sampling
- Publication
Archives of Dermatological Research, 2021, Vol 313, Issue 10, p863
- ISSN
0340-3696
- Publication type
Article
- DOI
10.1007/s00403-021-02186-2