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- Title
Zur Pathogenese der Isoniazid-Neuropathie.
- Authors
Schröder, J.
- Abstract
In INH-neuropathy sensory nerve endings of distal muscle spindles may be severely altered. The changes are characterized by a disappearance of synaptic vesicles, mitochondrial swelling or condensation, fragmentation of axon terminals and reactions of the corresponding intrafusal muscle fibers. Also, occasional alterations in lumbosacral spinal ganglia and spinal cord were seen occurring already in the initial stage of INH-neuropathy at the 4th day after the beginning of INH application. The perikaryal changes resemble those of the retrograde cell reaction. Any specificness of the alterations seen in the sensory endings of muscle spindles cannot be ruled out at the present time since there are no comparable fine structural studies of pathological alterations in muscle spindles after simple nerve section or other nerve lesions.
- Publication
Acta Neuropathologica, 1970, Vol 16, Issue 4, p324
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/BF00686896