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- Title
Association of metformin treatment with enhanced effect of anti-VEGF agents in diabetic macular edema patients.
- Authors
Shao, Yan; Wang, Manqiao; Zhu, Yimeng; Li, Xiaorong; Liu, Juping
- Abstract
Purpose: To investigate the effect of metformin combined with anti-VEGF agents in patients with diabetic macular edema (DME). Methods: This study was a prospective, nonrandomized case–control study. Patients were included in with a diagnosis of DME who received anti-VEGF agents injection. Basic information, medical history, best-corrected visual acuity (BCVA), central macular thickness (CMT), the number of intravitreal injections, panretinal photocoagulation (PRP), and macular grid photocoagulation treatment during the 6-month follow-up, were recorded for each patient. Results: A total of 50 DME patients were collected (24 patients with a history of oral metformin ≥ 6 months and 26 patients who had not taken metformin). The BCVA and the CMT were significantly improved after anti-VEGF treatment in two groups (F1 = 19.35, F2 = 26.78; F1 = 65.45, F2 = 76.23; P < 0.05). The BCVA in the metformin group was better than that in non-metformin group at every point after treatment (F = 34.45, P < 0.05). The CMT in metformin group decreased much more than that in non-metformin group during the follow-up period (F = 87.05, P < 0.05). The injection numbers decreased in the metformin group compared with the non-metformin group (t = 5.14, P < 0.05). However, there was no difference in PRP and macular grid photocoagulation therapy between the two groups during the 6-month follow-up. Conclusion: Metformin can enhance the therapeutic effect of anti-VEGF agents on DME patients to improve their visual acuity, improve the structure of the macular area, and reduce the number of intravitreal injections 90.
- Subjects
VASCULAR endothelial growth factor antagonists; MACULAR edema; METFORMIN; TREATMENT effectiveness; INTRAVITREAL injections; VISUAL acuity
- Publication
Acta Diabetologica, 2022, Vol 59, Issue 4, p553
- ISSN
0940-5429
- Publication type
Article
- DOI
10.1007/s00592-021-01833-4