We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
Mesangial cell‐predominant gene, megsin.
- Authors
Inagi, Reiko; Miyata, Toshio; Imasawa, Toshiyuki; Nangaku, Masaomi; Kurokawa, Kiyoshi
- Abstract
We identified a novel gene, termed megsin, predominantly expressed in mesangial cells utilizing a 3′‐directed regional cDNA library from cultured human mesangial cells. Megsin is a novel serine protease inhibitor (serpin), and the level of megsin RNA/protein expression is up‐regulated in patients with IgA nephropathy or diabetic nephropathy, suggesting a link between megsin expression and the pathogenesis of mesangial expansion and/or proliferation. To assess the pathophysiological significance of megsin, we produced human megsin transgenic mice. Genetic manipulation of megsin engenders two elementary mesangial lesions, mesangial expansion and an increase in the number of mesangial cells.
- Publication
Nephrology Dialysis Transplantation, 2002, Vol 17, p32
- ISSN
0931-0509
- Publication type
Article
- DOI
10.1093/ndt/17.suppl_9.32