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- Title
Phosphorus‐nitrogen compounds. Part 39. Syntheses and Langmuir‐Blodgett thin films and antimicrobial activities of N/N and N/O spirocyclotriphosphazenes with monoferrocenyl pendant arm.
- Authors
Asmafiliz, Nuran; Civan, Mehmet; Özben, Arda; Kılıç, Zeynel; Ramazanoğlu, Nagehan; Açık, Leyla; Hökelek, Tuncer
- Abstract
The Cl substitution reactions of the N/N (<bold>1</bold>‐<bold>3</bold>) and N/O (<bold>4</bold> and <bold>5</bold>) spirocyclic monoferrocenylphosphazenes with 1,4‐dioxa‐8‐azaspiro[4,5]decane (DASD) produce the mono‐ (<bold>1a</bold>‐<bold>5a</bold>), geminal‐ (<bold>1b</bold>‐<bold>5b</bold>) and tetrakis‐DASD‐substituted ferrocenylspirocyclotriphosphazenes (<bold>1c</bold>‐<bold>5c</bold>). The mono‐ and geminal‐DASD‐substituted phosphazenes have two and one stereogenic P‐centers, respectively. The structures of the compounds were established by spectroscopic techniques. The molecular structures of <bold>3a</bold> and <bold>2b</bold> were evaluated using X‐ray crystallography. Additionally, the ultrathin and highly ordered Langmuir‐Blodgett (LB) films of <bold>3a</bold> and <bold>2b</bold> were also prepared. The characterizations of the LB films were done using p‐polarized grazing angle (GAIR) and horizontal attenuated total reflectance (HATR) techniques. On the other hand, the antimicrobial activities of the eight phosphazene derivatives against G(+) and G(‐) bacteria and fungi were investigated. Furthermore, the interactions between the compounds and plasmid DNA were studied by agarose gel electrophoresis.
- Subjects
NITROGEN compound synthesis; PHOSPHORUS; THIN films; ANTI-infective agents; CYCLOTRIPHOSPHAZENES; PHOSPHAZENES; MOLECULAR structure
- Publication
Applied Organometallic Chemistry, 2018, Vol 32, Issue 4, p1
- ISSN
0268-2605
- Publication type
Article
- DOI
10.1002/aoc.4223