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- Title
History of Changes in the Protocol of Clinical Trial of Zinc Supplementation in Treatment of COVID-19 by Hydroxychloroquine.
- Authors
Sornsil, Dorn; Harada, Kouji H.; Phosri, Arthit
- Abstract
An article published in this journal used a randomized controlled trial to evaluate the efficacy of combining chloroquine/hydroxychloroquine (CQ/HCQ) and zinc in the treatment of COVID-19 patients. Findings from this study indicate that zinc supplements did not enhance the clinical efficacy of hydroxychloroquine in improving COVID-19 treatment. Although this finding is consistent with many previous studies, several concerns regarding study protocol and trial registration, including interventions and primary outcomes, have been raised in which the protocol has been changed after the completion of the recruitment.
- Subjects
COVID-19 treatment; RESEARCH protocols; ZINC; HYDROXYCHLOROQUINE; ZINC supplements; COVID-19
- Publication
Biological Trace Element Research, 2024, Vol 202, Issue 5, p1926
- ISSN
0163-4984
- Publication type
Article
- DOI
10.1007/s12011-023-03807-9