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- Title
Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell.
- Authors
Messaoudi, Hiba; Yaşa Atmaca, Göknur; Türkkol, Ayşegül; Bilgin, Mehmet Dinçer; Erdoğmuş, Ali
- Abstract
This study demonstrates the potential of sono-photodynamic therapy as an effective approach for enhancing singlet oxygen generation using the synthesized Schiff-base diaxially substituted silicon phthalocyanines. In photochemical studies, the singlet oxygen quantum yields (Φ∆) were determined as 0.43 for Si1a, 0.94 for Q-Si1a, 0.58 for S-Si1a, and 0.49 for B-Sia1. In sono-photochemical studies, the Φ∆ values were reached to 0.67 for Si1a, 1.06 for Q-Si1a, 0.65 for S-Si1a, and 0.67 for B-Sia1. In addition, this study demonstrates the therapeutic efficacy of phthalocyanines synthesized as sensitizers on the PC3 prostate cancer cell line through in vitro experiments. The application of these treatment modalities exhibited notable outcomes, leading to a substantial decrease in cell viability within the PC3 prostate cancer cell line. These findings highlight the potential of utilizing these synthesized phthalocyanines as promising therapeutic agents for prostate cancer treatment.
- Subjects
REACTIVE oxygen species; PROSTATE cancer; CANCER cells; PHTHALOCYANINES; IN vitro studies; SILICON
- Publication
Journal of Biological Inorganic Chemistry (JBIC), 2024, Vol 29, Issue 3, p303
- ISSN
0949-8257
- Publication type
Article
- DOI
10.1007/s00775-024-02055-z