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- Title
MARINE GREEN ALGAE-DERIVED OLIGOSACCHARIDES AND THEIR POTENTIAL PHARMACEUTICAL APPLICATIONS.
- Authors
Zhao Chao
- Abstract
Oligosaccharides offer beneficial effects on immune system and gut health, such as immunomodulatory activity, anticancer activity, and complement activation. Functional oligosaccharides are widely found in plants, algae, bacteria, and higher fungi. The consumption of functional oligosaccharides can reduce the risk of lifestyle-related diseases, such as cardiovascular disease, cancer, obesity and type 2 diabetes. Marine macroalgae possess tremendous nutritional value and have been well-known to cure and prevent the chronic metabolic diseases. An increased interest in various bioactive natural products from marine macroalgae, as a potential source of effective agents, has been observed in recent years. Especially, green algae have attracted attentions for their important functional properties and potential biological applications. The effects of marine green algal oligosaccharides may delay the development of chronic metabolic diseases such as diabetes, and alter the metabolic abnormalities through various mechanisms of actions. Marine green algal oligosaccharides used to prevent and manage diabetes. The excellent performance was based on their chemical structures and glycosidic linkages. Our research is focus on structures, accessible sources, physiological and chemical characteristics, and potential health benefits of green algal functional oligosaccharides. Moreover, the project aims to to carry out research on new key gene mining and regulation mechanism of marine green algal functional oligosaccharides to dietary interventions for glucose metabolism. Our group engages in the nutritional evaluation research of functional components from marine algae and has achieved a series of original results: to firstly report the largest gram scale production of fucosylated oligosaccharide lacto-N-fucopentaose I, to firstly discovered the COL1A1 as one potential new biomarker and therapeutic target for type 2 diabetes, to reveal the new mode of regulation of algal oligosaccharides on glycometabolism network based on microRNAs, and to elucidate systematically molecular mechanisms of marine algal oligosaccharides to regulate glucose metabolism via mediating intestinal flora. These results make the important breakthrough in the theoretical basis of algal food nutrition and successfully realize them transformation and application.
- Subjects
OLIGOSACCHARIDES; MARINE natural products; TYPE 2 diabetes; MARINE algae; GREEN algae
- Publication
Genetics & Applications, 2024, p15
- ISSN
2566-2937
- Publication type
Article