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- Title
利用转录组初步探索曲古抑素 A 延缓香菇菌丝转 色机制.
- Authors
吴涛; 鲍大鹏; 王伟霞; 仝乐涛; 李福后; 唐利华
- Abstract
Histone deacetylation is one of the most important epigenetic modifications and plays a variety of roles in development, but the detailed function and mechanism of histone deacetylation in Lentinula edodes is unknown. An extensive deacetylation inhibitor (HDACi), trichostatin A (TSA) was used to determine the role of histone deacetylation on the developmental process of Lentinula edodes. It was observed that exogenous application of TSA could inhibit the process of ripening and brown mycelium film formation of pack-cultured Lentinula edodes. Transcriptomic analysis revealed that TSA treatment produced 393 differentially expressed genes, which were mainly enriched in the biosynthesis of secondary metabolites, protein processing in the endoplasmic reticulum, and microbial metabolism in different environments. Analysis of the differences in gene expression between TSA treatment and control groups indicated that TSA might directly or indirectly affect the genes of cytochrome P450, laccase, and glycoprotein family by affecting histone acetylation levels, and thereby exert an influence on the formation of Lentinula edodes brown mycelium membrane. This paper provides a reference helpful to shortening the cycle of industrial production of Lentinula edodes.
- Publication
Mycosystema, 2024, Vol 43, Issue 6, p1
- ISSN
1672-6472
- Publication type
Article
- DOI
10.13346/j.mycosystema.230287