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- Title
结直肠癌患者血清miRNA-767-3p水平及其诊断意义.
- Authors
陈玉琢; 刘海宁; 刘韬韬
- Abstract
Objective To assess potential diagnostic value of miRNA-767-3p in colorectal cancer (CRC). Methods The serum miRNA-767-3p levels in CRC patients, colorectal adenoma patients and healthy people were determined using real time quantitative PCR (qRT-PCR).The concentration of carcino embryonic antigen (CEA) was detected via chemiluminescent immunoassay (CLIA) in above three groups. Receiver operating curves (ROC) were established to evaluate the diagnostic efficiencies of miRNA-767-3p and combination with CEA in CRC patients. Results The levels of miRNA-767-3p were declined in CRC patients, colorectal adenoma patients and healthy people, respectively. ROC curves illustrated that the area under ROC curve (AUC) of miRNA-767-3p was up to 0.770 (95%CI:0.698-0.842),with sensitivity of 80% and the specificity of 68% in CRC diagnosis. Moreover, a higher AUC up to 0.862 (95%CI:0.806-0.918) with the sensitivity of 73% and the specificity of 84% was achieved when miRNA-767-3p and CEA were combined. Conclusions Serum miRNA-767-3p could be considered as an independent diagnostic marker of CRC, and miRNA-767-3p combined with CEA would increase the detective quantum efficiency of CRC.
- Publication
Fudan University Journal of Medical Sciences, 2018, Vol 45, Issue 1, p52
- ISSN
1672-8467
- Publication type
Article
- DOI
10.3969/j.issn.1672-8467.2018.01.008