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- Title
Anti-Inflammatory and Antioxidant Properties of Crude Methanol Extracts from the Flowers and Peels of Khlong Seng Local Durian (Durio Zibethinus Murr.).
- Authors
Surachai Sang-Ngam; Worrawat Promden; Naunpun Sangphech; Arnon Chukaew; Siriluk Sintupachee
- Abstract
The agricultural byproduct, represented by durian peels during the season, needs to be converted into economic value within the local area. This study aimed to assess the pharmaceutical properties, specifically antioxidant and anti-inflammatory effects, of methanol extracts from both flowers and peels of the local durian in the district. Additionally, in vitro testing was conducted to evaluate the impact on cells and the inhibition of nitric oxide induced by LPS. Results indicated that the flowers' extract exhibited a higher concentration of antioxidants compared to the peels. The FRAP assay, using Trolox and Fe(II) as standards, showed statistically significant differences (p-value < 0.05) with values of 427.40 ± 7.64 μmole TE/g extract and 3,568.47 ± 77.55 μmole Fe(II) equivalent/g extract, along with a DPPH scavenging of 85.19 % and an IC50 of 114.50 ± 7.27 μg/mL. Concerning the inhibition of LPS-induced nitric oxide content, the peels' extract, excluding KS7, demonstrated a response. KS10 exhibited the highest statistically significant difference (p-value < 0.05) in inhibition at concentrations of 0.6, 0.8 and 10 μg/mL, while others showed inhibition at 1.0 μg/mL. The outcomes of this research suggest the potential to enhance the value of agricultural waste, contributing to both the development of durian agriculture and public health at the local level.
- Subjects
DURIAN; AGRICULTURAL wastes; AGRICULTURAL development; FLOWERS; VALUE (Economics)
- Publication
Trends in Sciences, 2024, Vol 21, Issue 7, p1
- ISSN
2774-0226
- Publication type
Article
- DOI
10.48048/tis.2024.7793