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- Title
Analysis of Global Oxidative Status Using Multimarker Scores Reveals a Specific Association Between Renal Dysfunction and Diuretic Therapy in Older Adults.
- Authors
Rodríguez-Sánchez, Elena; Navarro-García, José Alberto; Aceves-Ripoll, Jennifer; González-Lafuente, Laura; Corbacho-Alonso, Nerea; Baldan-Martín, Montserrat; Madruga, Felipe; Alvarez-Llamas, Gloria; Barderas, María G; Ruilope, Luis M; Ruiz-Hurtado, Gema
- Abstract
Aging and chronic kidney disease (CKD) are important interrelated cardiovascular risk (CVR) factors linked to oxidative stress, but this relationship has not been well studied in older adults. We assessed the global oxidative status in an older population with normal to severely impaired renal function. We determined the oxidative status of 93 older adults (mean age 85 years) using multimarker scores. OxyScore was computed as index of systemic oxidative damage by analyzing carbonyl groups, oxidized low-density lipoprotein, 8-hydroxy-2'-deoxyguanosine, and xanthine oxidase activity. AntioxyScore was computed as index of antioxidant defense by analyzing catalase and superoxide dismutase (SOD) activity and total antioxidant capacity. OxyScore and AntioxyScore were higher in subjects with estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 than in peers with eGFR >60 mL/min/1.73 m2, with protein carbonyls, catalase, and SOD activity as major drivers. Older adults with a recent cardiovascular event had similar OxyScore and AntioxyScore as peers with eGFR >60 mL/min/1.73 m2. Multivariate linear regression analysis revealed that both indices were associated with decreased eGFR independently of traditional CVR factors. Interestingly, AntioxyScore was also associated with diuretic treatment, and a more pronounced increase was seen in subjects receiving combination therapy. The associations of AntioxyScore with diuretic treatment and eGFR were mutually independent. In conclusion, eGFR is the major contributor to the imbalance in oxidative stress in this older population. Given the association between oxidative stress, CKD, and CVR, the inclusion of renal function parameters in CVR estimators for older populations, such as the SCORE-OP, might improve their modest performance.
- Subjects
SPAIN; OLDER people; KIDNEY diseases; OXIDANT status; GLOBAL analysis (Mathematics); EPIDERMAL growth factor receptors; DIURETICS; CHRONIC kidney failure; RESEARCH; CROSS-sectional method; RESEARCH methodology; ANTIOXIDANTS; MEDICAL cooperation; EVALUATION research; OXIDATIVE stress; COMPARATIVE studies
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2021, Vol 76, Issue 7, p1198
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glab012