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- Title
Systemic and Metabolic Signature of Sarcopenia in Community-Dwelling Older Adults.
- Authors
Lu, Yanxia; Karagounis, Leonidas G; Ng, Tze Pin; Carre, Christophe; Narang, Vipin; Wong, Glenn; Tan, Crystal Tze Ying; Nyunt, Ma Shwe Zin; Gao, Qi; Abel, Brian; Poidinger, Michael; Fulop, Tamas; Bosco, Nabil; Larbi, Anis; Zin Nyunt, Ma Shwe
- Abstract
<bold>Background: </bold>Evidence suggests the pivotal contribution of nutrition as a modifiable risk factor for sarcopenia. The present cross-sectional study characterized the nutritional and metabolic profile of sarcopenia through an extensive exploration of a wide array of blood biomarkers related to muscle protein metabolism and transcriptomic signatures in community-dwelling elderly adults.<bold>Methods: </bold>Among 189 older individuals with a mean age of 73.2 years, sarcopenia was diagnosed according to the Asian Working Group for Sarcopenia criteria based on appendicular lean mass measured by dual-energy X-ray absorptiometry scan, muscle strength, and gait speed. Nutritional status was evaluated using the mini-nutritional assessment (MNA). In addition, we assessed specific blood biomarkers of nutritional status (plasma essential amino acids [EAAs], vitamins), nicotine-derived metabolites, and an extensive microarray analysis from peripheral blood mononuclear cells.<bold>Results: </bold>Malnutrition defined by low MNA score was independently associated with sarcopenia (p < .001). Sarcopenic elderly showed lower body mass index and leptin and higher adiponectin and high-density lipoproteins. Levels of EAAs including lysine, methionine, phenylalanine, threonine, as well as branched-chain AAs and choline, were inversely associated with sarcopenia. Furthermore, nicotine metabolites (cotinine and trans-3'-hydroxycotine) and vitamin B6 status were linked to one or more clinical and functional measures of sarcopenia. Differentially expressed genes and ingenuity pathway analysis supported the association of nutrition with sarcopenia.<bold>Conclusions: </bold>Herein, the characterization of a nutritional and metabolic signature of sarcopenia provides a firm basis and potential identification of specific targets and directions for the nutritional approach to the prevention and treatment of sarcopenia in aging populations.
- Subjects
SINGAPORE; SARCOPENIA; ESSENTIAL amino acids; DUAL-energy X-ray absorptiometry; METABOLIC profile tests; BODY mass index; RESEARCH; NUTRITIONAL assessment; PHOTON absorptiometry; CROSS-sectional method; RESEARCH methodology; GERIATRIC assessment; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; INDEPENDENT living; GENE expression profiling; LONGITUDINAL method; NUTRITIONAL status; METABOLISM
- Publication
Journals of Gerontology Series A: Biological Sciences & Medical Sciences, 2020, Vol 75, Issue 2, p309
- ISSN
1079-5006
- Publication type
journal article
- DOI
10.1093/gerona/glz001