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- Title
Integration of cytokine and heterologous receptor signaling pathways.
- Authors
Bezbradica, Jelena S; Medzhitov, Ruslan
- Abstract
Cytokines are soluble mediators of cell communication that are critical in immune regulation. They induce specific gene-expression programs in responsive cells. Recent findings, however, indicate that cytokine receptors can regulate immune cell functions by transcription-independent mechanisms. Here we review the current understanding of how cytokine signaling regulates the functions of other signaling pathways by first discussing the 'traditional' transcription-mediated consequences of cytokine signaling and then providing a detailed description of transcription-independent lateral communications between cytokine receptors and other cellular receptors.
- Publication
Nature Immunology, 2009, Vol 10, Issue 4, p333
- ISSN
1529-2908
- Publication type
Article
- DOI
10.1038/ni.1713