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- Title
Killing curve activity of ciprofloxacin is comparable to synergistic effect of β-lactam-tobramycin combinations against Haemophilus species endocarditis strains.
- Authors
WESTH, HENRIK; FRIMODT-MØLLER, NIELS; GUTSCHIK, ERNÖ; BANGSBORG, JETTE
- Abstract
Nine Haemophilus species strains, all β-lactamase negative, isolated from patients with endocarditis were tested in killing curve experiments. Antibiotics used were penicillin, amoxicillin, aztreonam alone and in combination with tobramycin, as well as ciprofloxacin alone. Synergism between β-lactams and tobramycin with reduction of colony counts to zero was seen after 24 h for H. influenzae, H. parainfluenzae and H. segnis strains. Ciprofloxacin was as effective as β-lactam-tobramycin combinations. The H. aphrophilus strain was not killed as effectively as other strains by any of the antibiotics.
- Publication
APMIS, 1992, Vol 100, Issue 7-12, p856
- ISSN
0903-4641
- Publication type
Article
- DOI
10.1111/j.1699-0463.1992.tb04011.x