We found a match
Your institution may have access to this item. Find your institution then sign in to continue.
- Title
大蒜素对全脑缺血再灌注大鼠脑保护机制的研究.
- Authors
黄冬冬; 刘冬梅; 孙汝智; 吴晓华; 崔福江; 刘明清; 李清君
- Abstract
Objective: Through the observation of allicin preconditioning, observing the expression on cerebral ischemia-reperfusion in ICAM-1 area of hippocampus in rats, to study the mechanism of cerebral protection of allicin. Methods: 30 male Wistar rats, were randomly divided into 5 groups: sham operation group, ischemia reperfusion group, ischemia reperfusion+garlicin 10, 20, 30 mg/kg group. By four vessel occlusion methods for the preparation of rats with global cerebral ischemia reperfusion model in 24 h after reperfusion, removing the hippocampus, thionine staining to observe morphological changes of hippocampal tissue, Immunohistochemical staining was measured hippocampal CA1 area of ICAM-1 immunoreactivity and integral optical density of positive cells. Results: By giving complete cerebral ischemia 8min reperfusion in rats 24 h, morphology of hippocampal CA1 area organization changed significantly, neuron density decreased significantly; the expression of ICAM-1 increased significantly. Intravenous administration of allicin can make ischemia and morphology of hippocampal tissue perfusion changes significantly improved, the number of survival neurons increased, the expression of ICAM-1 was significantly less. Conclusion: Allicin can reduce ICAM-1 by inhibiting the expression and play a role in brain protection after cerebral ischemia - reperfusion inflammation loss.
- Publication
Progress in Modern Biomedicine, 2015, Vol 15, Issue 35, p6848
- ISSN
1673-6273
- Publication type
Article
- DOI
10.13241/j.cnki.pmb.2015.35.012